What does this term mean?It’s a common noun term used to describe a cancerous or almost-Cancerous tissue. Many people may be thinking of cervical cancer, for example, but it can also mean breast cancer, uterine cancer, uterine lymphoma, cervical cancer or some portion of both. “Cervical cancer is one of the most common cancer-causing tumors in women, and it can be thought of as a triple threat:” says Sumanth Bal, MD, Esctofemika H.S., director of the Women’s Medical Group of India Mission, Medanta Hospital, Mumbai, India. As women age, the number of cervical cancers increase. “Cancers in both head and neck are fairly common in both middle age and old age. In India, cervical cancer is 2.3 million cases annually, along with 0.5 million cases of prostate cancer and a million female breast cancer,” says Bal, who wrote this piece with BJP National Executive Committee member Madhavi Bhargava for the purpose of the annual VIETNAM 2019 and the Research Messageboard for the upcoming F&A+ Conferences in Mumbai, India.
The FactsAccording to the National Breast Cancer Foundation (NBCF) Cancer Data Bank, India, about 99.2% of all new cases of cervical cancer are among young women 15 to 24 years of age and 14.1% are woman aged 50 years or more. According to the National Cancer Control Organization (NCO), about 95 of 100 women with advanced cervical grade tumors would have been alive without the use of hormone therapy or other alternative therapies. Though hummus, chemotherapy, injections and herbal therapy can benefit a tiny number of women with cervical cancer, that is all a woman needs.
The main causes of cervical cancer however are hereditary (genetic), lifestyle (e.g. HPV), and environment (e.g. smoking, douching or having a hormonal imbalance) – such as environmental pollutants. Overall, women with hereditary cancer are more likely to recover from retrograde cervical movement, a cervical lesion, and fail to go into a gynecological cancer remission.
It is known that the development of cervical cancer is primarily due to a mutation in the ZIKV strain (arc) of human papilloma virus (HPV) that determines the development of cancer. One of the mutations identified in the ZIKV HPV strain (HPV-6) and the one prevalent among India’s multi-racial population, features of the ZIKV strain include mutations in the LCX8CT1 gene and LCX7CT1. This gene encodes a protein that creates the upper and lower basal cervical mucosa, an integral part of the cervical lymph system.
The PAC ReadoutA newly-published update on RNA (targeted RNA), that is an epigenetic modification on DNA, may play a crucial role in the ability to predict and treat advanced cervical cancer. Earlier studies revealed that a patient’s tumor cellular profile (not age, sex, etc.) and genetic make-up shows an excellent predictive role for future cervical cancer.
The update – which was published in its ninth edition in 2017 – also describes the Medical Oncology Branch of the NCORI as showing a ‘full potential ‘to investigate more, verify more’ important cancer biomarkers than the current availability of conventional biochemical tests for prostate, bladder, bladder & head and neck cancers. “Dr Thomas Thcke has compiled an excellent new resource for the field, which clearly demonstrates the full potential of these brain areas for making advances in cancer research,” says Rita C. Breoting, MD, Ph.D., chair of the Council on Retina & Ageing Research at the NCORI.