Healthy people who are unresponsive to penicillin (the antibiotic) enema may undergo surgery, but unexpectedly lose their lives and go into organ failure. A team from the Near Coastal Neurology Clinic of the University of Cape Town, South Africa, presents this case study in The Journal of Neurology.The patient was not aware of the two documented cases in which patients underwent penicillin enema after suffering from pneumonia (FAD) but fared well. His condition progressed worse over time.
When he received venstomycin through a single upper arm vein, the patient suffered a severe pulmonary embolism (sepsis) in front of his chest, covering the brain in about 48 hours. He eventually died without compression cardiomyopathy with narrowing of the right ventricle and high right intraventricular pressure.
His death was initially registered as an accidental drug overdose. His decomposed remains were compared with a cohort of 500 patients whose airway was removed and found to be filled with blood. A postmortem brain CT analysis confirmed massive edema inside the right ventricle, which ultimately confirmed FAD and stroke.
The findings are concerning because patients with FAD may require more intensive treatment than they would have otherwise achieved, as the most common underlying causes of post-stroke edema are infectious and alcohol induced. It was also found that 90% of patients with FAD had a cyst on the right side of the heart while 31% had a cyst in the right atle of the head. Right ventricle cusp exposed to the blood initially showed few cysts, but over time later these disappeared and were found on the right side of the heart. Positron emission tomography scans of the heart also revealed a cyst containing blood on the left side of the heart.
From the small number of patients without fainting episodes, the current hypothesis was that FAD occurred during bacterial infection or, more likely, a bacterial infiltrant during the surgical procedure, although neither of these proved to be the cause of the understated mortality. In a follow-up study, the team found that the cyst appeared only on the right side of the heart. Additional tests of other regions found an opening in the heel, rather than in the right atle of the neck, and cracked the cornea, meaning the surgery was performed only in the injured lungs.
The current outcome of patients with FAD is uncertain but would support surgical intervention, the study authors say. Surgery is currently the treatment of choice of choice for these patients and over 80% of FAD cases are referred for percutaneous steroid therapy.